Student Ph.D. Defense - Haneen Omar

Nov 06 2018 12:00 AM - Nov 06 2018 12:00 AM

Design and Synthesis of Porous Smart Materials for Biomedical Applications

DATE:
Tuesday, November 06, 2018
TIME:
10:00 AM - 11:00 AM
LOCATION:
Al Jazri, Building 4, Level 5, Room 5220


Abstract:  Porous materials have garnered significant interest within the scientific community mainly because of the possibility of engineering their pores for selective applications. Currently, much research has focused on improving the therapeutic indices of the active pharmaceutical ingredients engineered with nanoparticles.

In this dissertation, we engineer the pores of inorganic and hybrid porous materials to produce novel stimuli-responsive degradable nanosystems for controlled release of cargos for biomedical applications. The design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells is described. The mesopores of the nanomaterials span 20 to 60 nm in diameter, and post-functionalization allowed the electrostatic immobilization of large proteins (e.g., mTFP-Ferritin, ~534 kDa). The presence of iron oxide nanophases allowed for the rapid biodegradation of the carrier in fetal bovine serum as well as magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus very promising for biomedical applications.