An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides

Z.Q. Weng, W.M. He, C.H. Chen, R. Lee, D. Tan, Z.P. Lai, D.D. Kong, Y.F. Yuan, K.W. Huang
Angew. Chem. Int. Ed., 52, 1548-1552, (2013)

An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides

Keywords

Trifluoromethylthiolation

Abstract

​A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields.

Code

DOI: 10.1002/anie.201208432

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