Microwave-induced chemotoxicity of polydopamine-coated magnetic nanocubes
K. Julfakyan, Y. Fatieiev, S. Alsaiari, L. Deng, A. Ezzeddine, D. Zhang, V.M. Rotello, N.M. Khashab
Int. J. Mol. Sci.,16, 18283-18292, (2015)
FeCo nanocubes, Polydopamine, Microwave radiation, Nanomedicine
Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized
and tested under microwave irradiation of 2.45 GHz frequency and 0.86
W/cm2 power. These particles were found to be non-toxic in
the absence of irradiation, but gained significant toxicity upon
irradiation. Interestingly, no increase in relative heating rate was
observed when the PDFCs were irradiated in solution, eliminating
nanoparticle (NP)-induced thermal ablation as the source of toxicity.
Based on these studies, we propose that microwave-induced redox
processes generate the observed toxicity.
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