Photoresponsive bridged silsesquioxane nanoparticles with tunable morphology for light-triggered plasmid DNA delivery

Y. Fatieiev, J. Croissant, S. Alsaiari, B.A. Moosa, D.H. Anjum, N.M. Khashab
ACS Appl. Mater. Interfaces, Article ASAP, (2015)

Photoresponsive bridged silsesquioxane nanoparticles with tunable morphology for light-triggered plasmid DNA delivery

Keywords

Bridged silsesquioxane,  DNA delivery,  Organosilica,  Hollow nanoparticles,  Charge reversal

Abstract

​Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene–ammonium bridges are described. The systematic screening of the sol–gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100–200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to −39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

Code

DOI: 10.1021/acsami.5b07365

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