“Two-Step” Raman imaging technique to guide chemo-photothermal cancer therapy

L. Deng, Q. Li, Y. Yang, H. Omar, N. Tang, J. Zhang, Z. Nie, N.M. Khashab
Chem. Eur. J, (2015)

“Two-Step” Raman imaging technique to guide chemo-photothermal cancer therapy

Keywords

Chemotherapy,  Gold nanorods,  Graphene oxide,  Photothermal therapy,  Surface enhanced Raman spectra

Abstract

​Graphene oxide-wrapped gold nanorods (GO@AuNRs) offer efficient drug delivery as well as NIR laser photothermal therapy (PTT) in vitro and in vivo. However, no real-time observation of drug release has been reported to better understand the synergy of chemotherapy and PTT. Herein, surface-enhance Raman spectroscopy (SERS) is employed to guide chemo-photothermal cancer therapy by a two-step mechanism. In the presence of GO as an internal standard, SERS signals of DOX (doxorubicin) loaded onto GO@AuNRs are found to be pH-responsive. Both DOX and GO show strong SERS signals before the DOX@GO@AuNRs are endocytic. However, when the DOX@GO@AuNRs enter acidic microenvironments such as endosomes and/or lysosomes, the DOX signals start decreasing while the GO signals remain the same. This plasmonic antenna could be used to identify the appropriate time to apply the PTT laser during chemo-photothermal therapy.

Code

DOI: 10.1002/chem.201502522

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