Pillararene-based supramolecular systems for theranostics and bioapplications

H. Zhu, Q. Li, L. Khalil Cruz, N. Khashab, G. Yu, F. Huang
Science China Chemistry, (2021)


Drug delivery, Self-assembly, Pillararene, Supra-amphiphile, Theranostics


​As an emerging type of important macrocycles for supramolecular chemistry, pillararenes and their derivatives have been widely studied and applied in numerous fields, which intensively promotes the development of chemistry, materials science and biology. Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have showed very promising results. Owing to easy preparation, reliable guest affinity, good biocompatibility and stability, pil-lararenes are frequently used to construct functional biomaterials. On one hand, pillararenes can either be used individually or form diversiform self-assemblies such as micelles, nanoparticles and vesicles to increase water solubility and biocom-patibility of drugs. On the other hand, it’s promising to modify solid materials like framework materials, silica nanoparticles and graphene oxides with pillararene derivatives to enhance their function and controllability. In this review, we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy, photodynamic/photothermal therapy, antimicrobials, bioimaging, etc. By introducing several typical examples, the design principles, preparation strategies, identifications and bio-applications of these pillararene-based supramolecular systems are described. Future challenges and directions of this field are also outlined.


DOI: https://doi.org/10.1007/s11426-020-9932-9


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