Niveen M. Khashab, Ph.D.

Faculty

Associate Professor of Chemical Science

Research Interest

Professor Khashab's research interests are in design, synthesis, and applications of "smart" programmable nanomaterials with emphasis on the controlled release and delivery aspects of the systems. These engineered materials are utilized for biomedical (delivery, sensing, and imaging), industrial (nanocomposites) and environmental (membranes synthesis) applications.

Biomedical Applications

Stimuli responsive nanomaterials are prepared to package and deliver drugs directly to diseased cells, which reduce the harm to healthy parts of the body. It also allows for the delivery of hydrophobic drugs that cannot be up taken by cells. The delivery containers range from carbon based materials to inorganic capsules such as silica nanoparticles. Sensors and imaging agents based on metallic clusters and particles are also designed for separate use or direct incorporation with the delivery system for enhanced theranostic effect.

Industrial Applications

Surface modification of nanomaterials affects many of their physical and chemical properties. Improving the dispersion and interaction of nanomaterials is a hot topic as it has direct industrial application especially in the field of nanocompsites. Interaction of functionalized nanomaterials with different polymer matrices leads to a new generation of thermally, mechanically, and/or electrically enhanced materials.

Environmental Applications

Designing nanomaterial support systems for different catalysts has impressive environmental implications as it boosts the recyclability of these catalysts, which eventually leads to "green" practices. It also increases and protects the activity of the catalysts, which makes this process commercially viable. Furthermore, incorporating the designed nanomaterials in membranes promotes their practical use for different environmental processes.

Selected Publications

  • Synthesis of Platinum Nanotubes and Nanorings via Simultaneous Metal Alloying and Etching
    Z. Huang, D. Raciti, D. Yu, L. Zhang, L. Deng, J. He, Y. Liu, N.M. Khashab, C. Wang, J. Go...
    J. Am. Chem. Soc., 138, 6332-6335, (2016)
  • Collapsed Polymer-Directed Synthesis of Multicomponent Coaxial-Like Nanostructures
    Z.Q. Huang, Y.J. Liu, Q. Zhang, X.X. Chang, A. Li, L. Deng, C.L. Yi, Y. Yang, N.M. Khashab...
    Nat. Commun., 7, 12147, (2016)
  • Photoresponsive bridged silsesquioxane nanoparticles with tunable morphology for light-triggered plasmid DNA delive...
    Y. Fatieiev, J. Croissant, S. Alsaiari, B.A. Moosa, D.H. Anjum, N.M. Khashab
    ACS Appl. Mater. Interfaces, Article ASAP, (2015)
  • Electrostatic assembly/disassembly of nanoscaled colloidosomes for light-triggered cargo release
    S. Li, B.A. Moosa, J.G. Croissant, N.M. Khashab
    Angew. Chem., Int. Ed., 54, 6804-6808, (2015)
  • Surface modification of multiwalled carbon nanotubes with cationic conjugated polyelectrolytes: fundamental interac...
    A. Ezzeddine, Z. Chen, K.S. Schanze, N.M. Khashab
    ACS Appl. Mater. Interfaces, 7, 12903-12913, (2015)
  • Selective magnetic evolution of MnxFe1-xO nanoplates
    H.-M. Song, J.I. Zink, N.M. Khashab
    J. Phys. Chem. C, 119, 10740-10748, (2015)
  • “Two-Step” Raman imaging technique to guide chemo-photothermal cancer therapy
    L. Deng, Q. Li, Y. Yang, H. Omar, N. Tang, J. Zhang, Z. Nie, N.M. Khashab
    Chem. Eur. J, (2015)
  • Microwave-induced chemotoxicity of polydopamine-coated magnetic nanocubes
    K. Julfakyan, Y. Fatieiev, S. Alsaiari, L. Deng, A. Ezzeddine, D. Zhang, V.M. Rotello, N.M...
    Int. J. Mol. Sci.,16, 18283-18292, (2015)
  • Seeded growth of ferrite nanoparticles from Mn Oxides: observation of anomalies in magnetic transitions
    H.-M. Song, J.I. Zink, N.M. Khashab
    Chem. Phys., 17, 18825-18833, (2015)
  • Colorimetric peroxidase mimetic assay for uranyl detection in sea water
    D. Zhang, Z. Chen, H. Omar, L. Deng, N.M. Khashab
    ACS Appl. Mater. Interfaces, 7, pp. 4589-4594, (2015)

Education

  • Ph.D. University of Florida, Gainesville, U.S., 2006
  • B.S. American University of Beirut, Lebanon, 2002

KAUST Affiliations

  • Advanced Membranes and Porous Materials Center (AMPMC)
  • Division of Physical Science and Engineering (PSE)

Research Interests Keywords

​Design synthesis smart programmable nanomaterials controlled release and delivery biomedical delivery